Sentence examples for via prolongation from inspiring English sources

The nanoparticulate drug delivery systems can improve the quality of antibacterial treatment by decreasing side effects and reducing the frequency of dosing via prolongation of drug residence time [5].

Notably in this regard, in preclinical models of selective If inhibitor, ivabradine reduces HR without perturbing cardiac output or blood pressure by increasing stroke volume via prolongation of diastolic filing time and potentially through effects on the extracellular matrix.

Furthermore, it is well accepted that an increased late INa is known to produce arrhythmogenic triggers, such as early afterdepolarizations (EADs) via prolongation of the cardiac AP or delayed afterdepolarizations (DADs) caused by a Na+-dependent diastolic Ca2+ overload and oscillatory SR Ca2+-release which may activate a transient inward current (ITi) [ 14, 17, 23].

Available APC resistance assays test for the APC anticoagulant effect via either prolongation of clotting time (e.g., activated partial thromboplastin time [aPTT], prothrombin time [PT], etc)., or by direct measurement of thrombin generation using a chromogenic substrate.

Thus, a mild heterochronic delay in sympathetic reactivity, caused by delayed adrenal gland maturation, can have important life-long effects at higher cognitive levels, via a simple prolongation of a sensitive period for positive contact with humans.

Interestingly, our study revealed that protein C levels influence the PT, indicating that protein C plays a role in PT prolongation via the inactivation of FV and FVIII in the PT system in vitro, similar to coagulation in vivo.

Contribution of this prolongation of refractoriness to the anti-arrhythmic effect of β-blockers can act via lengthening the minimum pathlength for reentry.

Medical technology may contribute to iatrogenic complications, including sudden death or myocardial infarction after valve replacement surgery, stroke after carotid endarterectomy, fluid overload after transfusions and infusions, unwanted prolongation of life via artificial life support, and hypoxic encephalopathy after potentially life-prolonging cardiopulmonary resuscitation.

Numerous studies have demonstrated the pivotal role of SIRT1 in lifespan prolongation in various species via regulating epigenetic and genetic events.

Furthermore, AAL-2 exerted an anti-hepatoma effect via inhibition of tumour growth and prolongation of survival time of tumour-bearing mice in vivo.

Thus, chronic lead exposure may give rise to disturbances in ventricular conduction and result in QT prolongation, through cardiac afterload, via lead-induced elevation in vascular resistance.