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Except, rather than face to face, mano a man, he keeps confronting him via machinery.
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Like, for instance, when asked to play a sport, the fMRI shows their brains responding in the same way as a healthy brain would, and in this way researchers conduct conversations, via the machinery, with them.
On the other hand, it is also suggested that ubiquitinated proteins are degraded via autophagic machinery as well, which is called selective autophagy.
These results indicate diverse roles for Dicer and Ago2 in mouse oocytes; they are not only involved in the miRNA pathway, but also drive the siRNA pathway and control gene expression via RNAi machinery.
However, if the protein is terminally misfolded, a secondary response is to transport these proteins to the cytosol, which contains all the catalytic enzymes necessary to selectively target (i.e. via ubiquitylation machinery) the misfolded proteins for proteasomal degradation (Meusser et al., 2005).
How EMT-like effects via cytoskeletal machinery such as actin may alter signaling pathways when combined with classical EMT inducers (growth factors such as EGF or the TGFβ family) is unknown, and this information would provide important clues as to how cross-modulation may occur.
Kvβ2 may link Kv1.2 channel via the T1-Kvβ2 intoracthen, to the axonal transport machinery via the Kvβ2-EB1 interaction.
Our data add the nucleolin-Stat1 complex as a novel functional partner for the cell differentiation program, which is uniquely poised to regulate the transcription machinery via Stat1 and nuclear metabolism via nucleolin.
Based on modeling and structural prediction it is tempting to speculate that aMBF1 might act as a single regulator or non-essential transcription factor, which directly interacts with DNA via the positive charged linker or the basal transcription machinery via its Zn ribbon motif and the HTH domain.
Finally, we conclude that the survival of HIV within the host requires direct control of the cellular machinery via the pivotal human proteins and indirect control via the proteasomes.
Thus, it is probable that BmRas exists generally in various tissues, but acts via different machineries in each organ.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com