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In this work, we investigated the effects of negative pressure, applied using a pump designed for Negative Pressure Wound Therapy (NPWT), on the process of wound healing in vitro via initiation of the Wnt signaling pathway.
Casein kinase 1, alpha 1 (CSNK1A1) regulates protein turnover via initiation of translation via EIF2 and participates in wnt signalling; a homologue CSKNK2A1 has been previously identified as an independent predictor of survival in squamous cell lung cancer [39].
The MYC-eIF4E axis contributes to resistance to PI3K/mTOR inhibitor via initiation of up-regulated cap-dependent translation [ 22].
IGF1 positively controls this pathway via initiation of signaling at the cell surface, affecting protein synthesis rates.
These findings suggested a role of lipopolysaccharide via initiation of innate immune mechanism(s) in metabolic disorders.
TGF-β is upregulated in AKI and has a direct, detrimental effect via initiation of renal tubular apoptosis and extracellular matrix deposition [ 28, 29].
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This suggests that the effect of ethnicity on heavy drinking works via reducing initiation of drinking rather than drinking volume.
Thrombin plays an important role in brain recovery after intracerebral hemorrhage [ 35], possibly via the initiation of neurogenesis [ 36] and angiogenesis [ 37].
Persistent, excessive ER stress triggers cell death [ 5, 6] via the initiation of apoptosis and the induction of CHOP or by activation of caspase-12-dependent pathways [ 7, 8].
The NOTCH pathway is frequently over activated in BC and is related to the development and maintenance of BCSCs possibly via the initiation of EMT-like processes (Pannuti et al, 2010; Lombardo et al, 2012; Smalley et al, 2012).
Most people in the current study's context are of Xhosa origin where male sexual socialisation via initiation schools is of paramount importance.
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