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Long-circulating nanoparticles (NPs) are promising drug delivery vehicles which target solid tumors via enhanced permeation and retention effect.
Our structure-based design strategy shows that these two conformations converge into one via enhanced protein-ligand hydrophobic interactions.
Furthermore, hypomagnesemia can potentially induce hypercoagulability, via enhanced adenosine diphosphate-induced platelet aggregation [ 75].
Irrespective of the cell donor age, aSerum compromises MSC function and survival via enhanced oxidative stress.
Key scientific information should be more accessible to the public via enhanced open communication across scientific disciplines.
Presently, HMB is thought to operate via enhanced recovery of damaged skeletal muscle tissue (Wilson et al. 2008).
12 Appropriately designed nanomedicines with tunable size parameters have been shown to accumulate preferentially in the solid tumors via enhanced permeation and retention effect.
In leukemia and MM cells increased glycolysis raises ATP levels, which activates ATP-binding cassette (ABC) transporters and confers drug resistance via enhanced drug efflux activity.
This indicates that the oncogenic role of MLL translocations is not via enhanced H3K4 methylation, but through the recruitment of secondary factors in tandem with the fusion partner.
Such knowledge is essential in the development of public health initiatives that aim to increase the wellness of the population via enhanced physical activity and reduced sedentary behaviors.
The particles could be targeted to tumors via enhanced permeability and retention (EPR) effect and by functionalizing the nanoparticle surface with appropriate antibodies or other targeting molecules.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com