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One compound had passed cell culture tests, but caused massive blood vessel deterioration in vivo.
Moreover, ultrastructural analysis revealed signs of vessel deterioration in notch3 mutants, including gaps in the arterial wall and the presence of blood cells outside of vessels.
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Due to an improper nanoparticle dispersion method after fabrication, the nanofluid with a higher volume fraction will show a settlement layer quickly at the vessel bottom, leading to considerable deterioration of heat transfer performance.
When performing CTA in pregnancy, deterioration in pulmonary vessel enhancement has been reported, probably due to hyperdynamic circulation with increased cardiac output, increased plasma volume, increased body weight and the more pronounced effects of a Valsalva manoeuvre [45, 87].
Other than the pressure-lowering effect of vasodilation in OLM, the inhibition of AGEs by OLM may be another pathway contributed to the improvement of the CRF-derived deterioration of blood vessels in CRF rats.
Furthermore, increase in the blood viscosity induces endothelial damage, inflammation, vascular wall hypertrophy, platelet aggregation, and deterioration in the blood vessels shear stress; all these factors increase risks of stroke and cardiac ischemia [ 5].
However, according to Parsa, this treatment may create a reduction of cerebral venous outflow through collateral vessels of the PWS, thus, potentially worsening cerebral and ocular blood flow anomalies which could lead to cerebral venous deterioration, increase in intraocular pressure, choroidal vessel dilatation, and detachment of the retina due to exudation.
Clinical manifestations are a result of diastolic LV dysfunction with dyspnea, predisposition to angina, and heart failure, and small vessel degeneration in brain and kidney with intellectual deterioration and renal failure.
Ultrastructural analysis confirmed the presence of dilated vessels in notch3 mutant fins and revealed that the vessel walls of presumed arteries showed signs of deterioration.
Oxytetracycline (Sigma-Aldrich) was added to the urine collection vessels of the metabolic cages to prevent bacterial deterioration.
In other persons, blood vessel damage is early and severe, coupled with serious deterioration of heart function.
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