Sentence examples for vesicle turnover from inspiring English sources
The aim of the present study is to verify whether it is taken up in storage vesicles and released in company with vesicle turnover.
In a head-to-head comparison of 18F-LMI1195 with 123I-MIBG in isolated perfused rabbit hearts, tracer washout after vesicle turnover was accelerated by electrical field stimulation.
Analogous to 131I-MIBG, the current in vitro tracer uptake study confirmed that 18F-LMI1195 is also stored in vesicles in PC12 cells and released along with vesicle turnover.
After 2 h of 18F-LMI1195 preloadintointo both cell lines, effects of stimulants for storage vesicle turnover (high concentration KCl (100 mM) or reserpine treatment) were measured at 10, 20, and 30 min. 131I-meta-iodobenzylguanidine (131I-MIBG) served as a reference.
Overexpression of SNAP29 in presynaptic neurons inhibited synaptic transmission, causing a defect in synaptic vesicle turnover by inhibiting disassembly of the SNARE complex.
Thus, while there is evidence that these organelles are secreted by neuronal activity, their overall number and contribution to release is minor when compared to synaptic vesicle turnover [45].
Two hypotheses may explain our results: 1° a disturbance of the anterograde/retrograde transport, in relation with the MAP function of STOP protein [1] [3]; 2° a disturbance of synaptic vesicles turnover, in relation with the action of the phosphorylated form of STOP protein [26].
Regardless of the mode of intra-Golgi transport, if we match these numbers with published observations about the Golgi, we can then ask whether this vesicle-based turnover rates are possible/realistic or else.
It is predominantly expressed in neurons where it appears to localize in the synaptic terminal and play a role in vesicle transport and turnover [ 18- 20].
In conclusion α-syn is a predominantly neuronal protein, which associates with lipid membranes and plays a role in synaptic vesicle function and turnover.
The mechanism of this influence on vesicle function and turnover may rely on the interaction of α-syn with phospholipase enzymes and associated lipid-mediated signal transduction.
