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Based on the signed distance assumption, several inexact Newton strategies are employed to solve the capillary and vesicle problems and guarantee the second-order convergence behavior.
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In addition, the method is also applied to study a binary-component vesicle problem.
As suggested for tral and BicC, the formation of 'actin spheres' (as a readout of vesicle trafficking problems) in Khc oocytes might cause defects in Gurken signaling.
Several of these genes encode ER-associated proteins or proteins that are predicted to require vesicle-dependent transport steps, suggesting that their deregulation might be caused by feedback mechanisms that sense problems in the vesicle trafficking pathway.
The problem of a vesicle transported by a fluid flow can present a large range of length scales.
In previous work [20], [21], [48], we presented implementations of multicompartment systems and resolved the problem of readjusting vesicle formation/composition as well as of losing specificity by using linkers consisting of biotinylated DNA single strands (biotin-ssDNA) that were anchored by long and flexible phospholipid-grafted biotinylated PEG tethers via streptavidin as a connector.
In this work, De Camilli and coworkers take advantage of the mice deficient in dynamin 1 and dynamin 3 to address an old and still controversially discussed problem of synaptic vesicle recycling, namely the role of bulk endocytosis (observed as early as in the seventies) in synaptic vesicle recycling and its relationship to the clathrin- and dynamin-dependent pathway.
The problem linked to readjusting the vesicle formation procedure and/or vesicle composition was addressed by incorporating invariable and universal anchoring sites into the membrane during vesicle formation (phospholipid-grafted biotinylated PEG tethers).
This is most likely to result from reduced glutamate release perhaps, as a result of problems with its transport into vesicles in an ATP-dependent manner.
Therefore, we have proposed that extracellular vesicle secretion represents a eukaryotic solution to the problem of trans-cell wall transport, especially for large molecules [9], [12].
The problem of the osmophoretic motion of a spherical vesicle situated at an arbitrary position between two infinite parallel plane walls is studied theoretically in the quasisteady limit of negligible Peclet and Reynolds numbers.
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