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Likewise, PKA phosphorylation of synapsins is reduced in barrelless mice suggesting impairments in synaptic vesicle mobilization [10], [39].
In this way, synapsin regulates the rate of synaptic vesicle mobilization and release in a phosphorylation-state-dependent manner [39].
The nearest homolog, WDR7, is involved in vesicle mobilization and Ca2+-dependent exocytosis at synapses.
In particular, the synapse relies on high ATP levels for maintenance of membrane potential and vesicle mobilization [ 5].
This is a well-done piece of work indicating that synaptotagmin VII has a specific role in synaptic vesicle mobilization.
Rabconnectin contributes to activation and deactivation of RAB3A, a small GTP-binding protein that is a positive regulator of vesicle mobilization and Ca2+ dependent exocytosis of neurotransmitter release at synaptic vesicles.
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This is in line with recent observations indicating that excitatory synapses onto CA1 pyramidal cells, during stimulation at increased frequency are largely dependent on fast refilling of synaptic vesicles, rather than mobilization of reserve vesicles (Ertunc et al. 2007).
A recent study has shown that LRRK2 may control synaptic vesicle storage and mobilization within the recycling pool through an unclear mechanism although LRRK2 was found to putatively interact with a number of proteins in synaptosomes involved in vesicular recycling including Dnm1 (24).
A Network of Three Types of Filaments Organizes Synaptic Vesicles for Storage, Mobilization, and Docking.
While some studies hypothesized a deficiency of DA exocytosis due to impaired vesicular packaging [28], others indicated a decline in the number of DA reserve pool vesicles available for mobilization [29].
Given that the selective release of cytokines can provide a mean for eosinophils to rapidly influence adjacent cells in normal or inflamed tissues, investigation of the mechanisms involved in the selective mobilization and vesicle-mediated secretion of specific cytokines, including IL-4 and other preformed cytokines, is extremely relevant.
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