15, 20 The current lead compounds could also prove very useful in combination therapy with known trypanocides (such as melarsoprol), as studies have revealed TryS-depleted T. brucei procyclics are significantly more susceptible to trypanocides.
Third, our experiments showed that for the decision tree learner C5 alignment-based features are very useful, but that a combination with position-specific features and certain chemical features is necessary for obtaining the best results.
It will be important to validate the gSG6 protein at a macro-geographic level and in conditions of low transmission/exposure; in this respect the identification and testing of additional salivary proteins with different immunogenic properties may prove very useful and, moreover, the use of combination(s) of antigens may help improving sensitivity.
We agree that these types of visualizations can be very useful for viewing the combinations of selected subsets of neurons.
However, despite the fact that the direct use of triglyceride substrates would be very useful, the presence of different combinations of polyunsaturated fatty acid moieties on the triglyceride skeleton, often leads to the formation of a mixture of metathesis products.
Nonetheless, Fogari et al 50 showed that the amlodipine/telmisartan combination has been very useful in decreasing urinary albumin excretion in hypertensive diabetic patients with microalbuminuria.
15 The mechanism of action of the DPP-4 inhibitors is complementary to that of metformin, which improves insulin sensitivity and reduces hepatic glucose production, 12 for this reason this combination can be very useful in the clinical practice, to achieve an adequate glycemic control.
In addition, coexpression data are very useful to reveal integrated networks in combination with protein protein interaction data (Lee et al., 2004a, b, 2008), to predict protein protein interactions (Cui et al., 2008), or the functions of gene products (Aoki et al., 2007).
Hence, an effective approach for identifying mixtures of drugs and effective combinations can be very useful in this regard.
