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Regardless, as a grunt who spent over a decade in retail, I am vividly aware of how easier access to cash could very substantially change the fortunes of many small businesses.
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As the Amazon ecologist Philip Fearnside has shown, a mixture does "not substantially change the impact of very large-scale plantations from the standpoint of biodiversity".
This is because even the simplest form of life is very complex, so it is very difficult to predict what will happen when you substantially change their genomes.
Unfortunately for Earth, the smaller number does not substantially change the risk factor, which though very small is real (to paraphrase a popular bumper sticker, just one killer asteroid can ruin your whole day).
Similarly, performing additional rounds of selection (be it very stringent, normal, or lenient) also does not substantially change the observed noise levels of the selected promoters.
Though remaining at very low prevalence relative to single infections, coinfections and their simultaneous transmission substantially change the behaviour of infectious dynamics.
Technology will substantially change the lives of individuals.
For some people, being married doesn't substantially change things.
Still, the station refused to substantially change its policies.
Urinary subscores did not substantially change.
But, main results did not substantially change.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com