Sentence examples for very substantially by from inspiring English sources

This could be envisaged as a very small primary Ca2+ release from an acid store (endosomes, lysosomes) being amplified very substantially by further Ca2+ release from both larger acid stores (zymogen granules) and the ER.

Pressed about his being "a victim or potential victim" of hacking he refused to "go into detail about what seems to be a case that has been very substantially investigated by all sorts of bodies.

So, for example, Barclays and Nationwide have increased their net lending very substantially - by £6.8bn and £4.8bn respectively.

Nonetheless, the human Ire1α crystals grown from protein that has been very substantially dephosphorylated by λ-phosphatase (see Materials and methods) clearly contain Mg2+-ADP at full occupancy.

We found that γH2AX foci were low in G1 and highest in S phase as expected, and very substantially increased by rucaparib in S phase.

Intriguingly, this effect was only observed in a sub-population of replicons, such that the second and third classes were very substantially affected by RITA treatment, whereas the seventh/eight/ninth classes were less affected.

Diet is also an important modifier of clinical penetrance in phenylketonuria, as mentioned in the " Introduction" to this review, where the penetrance of the condition can be very substantially reduced by restricting dietary phenylalanine (van Spronsen 2010).

HIFα prolyl hydroxylation by PHDs very substantially increases its binding to the von Hippel Lindau protein (pVHL), which acts as a targeting component for an E3 ubiquitin ligase complex and thus mediates rapid degradation of HIFα by the proteasome.

The practice of controlling the pumping rate of ESP installations by wellhead chokes can very substantially reduce the energy efficiency of the system.

"By investing new equity, Four Seasons' debt has been very substantially reduced and Terra Firma has brought stability to the company," Mr. Hands said in a statement.

Our liberty as citizens depends very substantially on our ability to safeguard ourselves against arbitrary interference and excessive control by the state.