Sentence examples for very substantial level from inspiring English sources

The NoVo Foundation that Jennifer Buffett leads may not rank among the largest foundations in the U.S., but it is one of the biggest family foundations led by a woman and it gives at a very substantial level: $56.7 million in grants in 2012, placing it in the 100 largest foundations by giving.

There is a very substantial level 1 evidence-base, evaluating pharmacological and cognitive behavioural therapies (CBTs), 19 20 although the latter are very seldom available.

A back pressure applied made it possible to conduct ECAP at a relatively low temperature of 350°C thus leading to a very substantial level of grain refinement.

For example, very substantial levels of differential recall accuracy between patients with bladder and laryngeal cancer would have been required to generate the very large difference in median patient intervals between these two cancers (2 vs 34.5 days, respectively).

However, despite the good fit between model and data for two of the datasets, we find that there could be very substantial levels of unexplained variance and the correlations would remain almost unaffected (Table 1).

In vitro, association of MOF with the MSL1-MSL3 subcomplex results in a very substantial enhancement of the level and substrate specificity of its histone acetyltransferase activity [ 36].

Therefore there is a clear hierarchy of improvements of these three goals: modest improvements in the reduction of noise and rise-time to 50% steady-state level, good improvements in rise time to steady state level, and very substantial improvements in mRNA usage.

Thus, the theoretical challenge is the very substantial one of linking the microscopic level to higher levels of description, transferring the physicochemical representation from the lowest level of concern to the highest, so that predictions of the materials properties faithfully reflect the underlying chemical characteristics.

At the same time, differences in wages across Educational Attainment levels were very substantial: An increase of one standard deviation in math scores was associated with a wage increase that was typically less than a quarter of the difference between those with a college degree and those with a high school diploma.

To test this, we used in silico evolution to demonstrate that while negative feedback can achieve only a modest improvement in protein noise reduction compared with the unregulated system, it can achieve good improvement in protein response times and very substantial improvement in reducing mRNA levels.

Apoptosis levels were relatively unaffected, although notably apoptosis levels were already very substantial in the Pten/Lkb1-double deficient normal urothelium (Fig. S2).