They've really shoe-horned quite a bit of technology into a very small case.
Whilst this aspect of the design may be beneficial to assessing the relationship between smoking exposure and the broad spectrum of cancer diseases, the study was largely hindered by a very small case-control based sample size (n = 132), matched on only a narrow range of potentially confounding variables.
Studies on argatroban therapy in critically ill patients with MODS and suspected or diagnosed HIT are limited to very small case series with conflicting results [ 13, 14].
The low validity at the local level was explained by the difficulty to differentiate signal from noise when very small case numbers were analysed.
34 However, a very small case series of adult patients with cystic fibrosis given intravenous iron for anaemia refractory to oral iron found that haemoglobin concentration and MCV rose significantly within days of therapy.
Previous studies have documented an association between VEGF expression and malignancy after gene expression profiling of a very small case series comprising only 20 cases, with 9 malignant tumours (Favier et al, 2002), and another used immunohistochemistry of paraffin-embedded samples in a single-centre, retrospective study of 105 tumours, only 8 of which were malignant (Salmenkivi et al, 2003).
While two previous investigations in a cohort of PFOS-exposed workers suggested a possible positive relation between high PFOS exposure and CRC, the findings were non-significant, based on very small case numbers, and reliant on indirect measures of exposure [ 14, 15].
The numbers of subjects carrying the variant with NSAID exposure were however very small (six cases and two controls, compared to 18 cases and eight controls not exposed to NSAIDs) and no firm conclusion can be drawn on this point.
Since the coefficient K η for a solidified epoxy is very small, two cases of K η = 10−10 0.1ηs) and 10−9(1ηs) were chosen in our simulation to obtain the approximate attenuation [22].
