Sentence examples for very significant concern is from inspiring English sources

A very significant concern is ensuring protection against brain aging.

One area of significant concern is custody.

"There is clearly a very significant concern re-emerging at the moment that we are seeing real issues surrounding the eurozone," he said.

"What we don't have now is demand, and that's a very significant concern". During the second quarter of 2001, the vacancy rate for downtown San Francisco jumped to 9.91% from less than 2% in the same period last year, according to Grubb & Ellis Co.

"This is a very significant concern for pollsters, some of whom have even gone on record to say so".

"There are very real and very significant concerns that have been given short shrift," Gavin Kearney, a lawyer for South Bronx Unite, told Judge Mary Ann Brigantti-Hughes.

Though a valid concern, this does not detract from very significant concerns about transparency in aggregate.

There is talk of breaking a blade up into multiple pieces, but "that's a very significant structural concern," said Mr. Stricker, who also noted that tower bases were getting too large to squeeze through underpasses.

Significant concern has been expressed over the last three decades about barriers faced by clinician-scientists and indeed their very survival.

Essential revisions: Although the majority of reviewers found this study very interesting and significant, some concerns were raised regarding the mechanistic insight, the way the manuscript presents its major conclusions and some technical issues of the assays as presented.

It is fair to say the numbers on this who have expressed concern are very significant indeed.