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Novartis' arthritis drug, it turns out, blocks that very protein.
Moreover, O-BG can elevate the mutagenicity of TMZ, as it inhibits the very protein (MGMT) that repairs its mutagenic adduct (O-meG) (Cai et al, 2000).
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Pepys was fond of very protein-heavy breakfasts, involving the likes of brawn.
And many of these are the very proteins to which drugs bind.
In our study, these very proteins were the ones that changed dramatically in response to coccidiosis.
We found that Nup98 FG domains assemble from (even dilute) aqueous solutions into very protein-rich phases that reject inert molecules ≥25 kDa in size, but at the same time allow influx of far larger NTR-complexes.
Ankyrin repeats mediate protein-protein interactions in very diverse proteins, including protein kinases and transcription factors [ 37].
However, very few protein-protein or protein-DNA interactions have been identified for any fish species.
These proteins form a very ancient protein family in eukaryotes that can be traced back to LECA.
The observed alterations are typically outside protein-coding regions or affect only very short protein segments.
For example, in very low protein diets P and K were shown to be increased, Ca was reduced in very low protein diets but protein intake had no effect on Mg concentrations in urine (Calloway and Margen, 1971).
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