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"Even a very modest risk would be a risk incurred by tens of millions of people with very real consequences," Dr. Brunelli said.
A short-term Treasury fund with an average maturity of two or three years will add maybe half a point to your aftertax return, at a very modest risk of principal loss should interest rates climb.
However, these variants will probably inflict very modest risk increments and physiologic characterization of such loci will be extremely challenging.
Then there are very common SNP genotypes of less utility that confer very modest risk modification for common disorders, such as type 2 diabetes mellitus [ 7].
Conceptually the framework involves hundreds or even thousands of very modest risk alleles but also some number of rare mutations with a much larger effect on risk for certain individuals.
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In addition, most variants seem to confer very modest risks in the order of 1.2 1.6 fold, which are hard to detect given the statistical difficulties described above.
In a separate finding, Dr. Gammon's study showed that exposure to polycyclic aromatic hydrocarbons, commonly found in pollutants like car exhaust and cigarette smoke, produced a very modest increased risk for breast cancer.
"But such large numbers of people in the country and the world engage in sand contact activities that, even with a very modest relative risk, you could see substantial disease burden".
Novel diabetes genes identified by genome-wide association studies, requiring tens of thousands of cases for sufficient statistical power, confer a very modest increase in risk of each risk allele (odds ratios: 1.1 1.2) (108).
Odds ratios presented both here and in the other two studies consistently show that total risk scores based on low-penetrant SNPs adds only very modest improvement to risk prediction models based on medical data, and are therefore not likely to have an immediate clinical use.
Compared with risk with <2 years of NPH use, there was some suggestion of a <span class="lh">very modest increase in risk of breast cancer associated with ≥5 years of NPH use (Supplementary Table 4).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com