Sentence examples for very large expansion from inspiring English sources

If Mr Graves is right about the theory and in the ball-park with his number, his analysis favours a very large expansion in efforts to improve the environment.

"Despite the serious shortcomings of the ERF, few of which are mentioned in the majority report let alone responded to, the majority report recommends a very large expansion of the scheme, to the point where Australia's entire emissions abatement effort, at least for several years, would depend on it".

Other significant groupings consist entirely of Arabadopsis sequences, reflecting the very large expansion of this family of phosphatases in plants (see Fig. 2), where PP2c enzymes play major roles in the mediation of stress responses [ 19, 58].

To exclude the presence of a very large expansion that would be missed by PCR in a case with homozygosity of a normal CAG-repeat allele, the use of a southern blotting protocol (PstI-digested DNA hybridized with probe 4G6P1.7) or TP-PCR is recommended (also see the next paragraph).

CTCF is displaced in the presence of very large expansions of a nearby CTG triplet-repeat sequence, resulting in spreading of antisense transcription and heterochromatin formation beyond their limited confines, leading to congenital myotonic dystrophy [33].

Very large expansions of this CUG repeat lead to a congenital form of DM1 characterized by intellectual disability and severe weakness; features that are not seen in adults with the disease.

Many economists, myself included, are calling for a very large fiscal expansion to keep the economy from going into free fall.

A very large volume expansion occurs during both Si and Si3N4 oxidations.

In more extreme situations like congenital DM with very large (CTG n expansions, where abnormal chromatin modification and defective bidirectional transcriptional control across the DM locus may directly couple to unbalanced DMPK production, the toxic effects of DMPK A may even directly contribute to special disease features [51], [52].

Sergeant et al. [ 32] have documented the presence of very large CTG expansions in brain tissue of DM1 patients characterized by much smaller size of CTG in lymphocytes.

Indeed, some investigators have proposed that very large repeat expansions might trigger temporally aberrant expression of the expanded repeat during early development as a result of local chromatin changes induced by the repeat expansion (Filippova et al., 2001; Cho et al., 2005; Cho and Tapscott, 2007).