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It is interesting to observe such a very large decrease in the oxidation potential in the absence of any redox mediator at the modified electrode.
The pure TiO2 films show a moderate variation of the impedance with RH, while the alkali-doped films show a very large decrease in resistance and a nearly constant capacitance with increasing RH.
This higher sensitivity to irradiation can be related to a very large decrease in thermal conductivity of nanocrystalline diamond, due to grain boundary confinement of the heat spike which enhances localized heating of the lattice.
In the presence of rapamycin, there was very large decrease in FRET efficiency in both cells transfected with 300 ng pBud-sol-sTEVp (to 7% of control median FRET efficiency; n = 23) and 1000 ng of pBud-sol-sTEVp (to 3% of control median FRET efficiency; n = 18), although a number of cells displayed variable FRET efficiencies.
Initial simulations would predict that such a reduction would result in a very large decrease in maximum ATP production in heart, which would seem likely to have catastrophic effects.
A significant decrease in serum hydrogen peroxide was seen during albumin and gelatin administration (p < 0.01, repeated measure ANOVA) and a very large decrease in serum lipid peroxides was observed during the albumin period only (p < 0.01, Friedman test).
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Similarly in both groups, there were very large decreases in submaximal HR (figure 3).
Inclusion of cytosolic enzymes gave very large decreases in DNA damage rates and amount of adducts (Fig. 4) for all organs except lung.
The S246I change is the most enigmatic because it would seem that Ile-246 could interact well with the adenine ring, but the S246I enzyme exhibited very large decreases in catalytic efficiency.
There were small-moderate decreases in stride rate (p < 0.01) and moderate-very large decreases in contact time (p < 0.01) with increases in BWS for both men and women.
Global brain analyses between AN patients versus healthy controls revealed a significant decrease in global gray matter volume, with a medium effect size of −0.66 representing a very large decrease.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com