It is somewhat lacking in terms of availability, scalability and write-performance, and it is very hindered by its stabilization time (which is also one of the reasons for its low availability).
Moreover, a tight fieldwork budget and other priorities very often hinder the inclusion of rather difficult and complex items in a questionnaire.
Conversely, replacement of threonine with asparagine at 426 (i.e., KaiCnST) very significantly hinders the rate of dephosphorylation.
They suggest that if levels are too high then dendritic spines will be excessively stable, impairing plasticity; likewise, if levels are too low then the spines will be very unstable, also hindering plasticity.
These two distinct food-producing strategies also prevail among sympatric populations of the African Sahel, but knowledge on NAT2 genetic variation among African pastoral nomads was up to now very scarce, thus hindering a meaningful statistical analysis of the likely differences between food-producing subsistence modes in sub-Saharan Africa (see Supporting Information in [ 38]).
And Romney's anti-gay-marriage stance doesn't seem to be helping or hindering him very much.
The differences observed among the samples prepared with alcohols were ascribed to the strong interaction produced between the silanization agent and the linear alcohols on the surface of the protozeolitic nanounits, which form a very stable protective layer, hindering their aggregation and subsequent crystallization.
In addition, due to the low level of differentiation (FST<0.1), the mode of the empirical (and simulated) distributions was very close to zero, hindering the identification of SNPs under balancing selection (with low FST).
In addition, dynactin contains two actin-related proteins of which Arp1 is closely related to actin while Arp10 is a very divergent member thus hindering their immediate identification.
They reflected on difficulties in implementing new routines, and saw the fact that work in PHC is carried out in a very traditional way as hindering work with lifestyle issues.
