Through genetic and biological analysis, we demonstrate that the nucS-null phenotypes in M. smegmatis are almost identical to those produced by the MMR deficiency in other bacteria (very high mutation rates, transition-biased mutational spectrum and increased homeologous recombination rates).
This constructed mutator has a very high mutation rate to phage resistance; it may have evolved very quickly to outpace the phage and thus rendered the phages unable to persist (Data S1), consistent with previous work of this system (Pal et al. 2007).
Because mitochondrial DNA has very high mutation rates compared with nuclear DNA, it has been useful for establishing relationships among groups that have diverged recently.
It is known that HIV-1 can present very high mutation and recombination rates, however the specific contribution of these evolutionary forces in the "in vitro" viral fitness recovery has not been simultaneously quantified.
In arguing whether this research should have been done, we must keep in mind that flu strains have very high mutation rates, and the disputed mutations could well have arisen naturally at any time.
Since BA has very strong exploitation potential, a very high mutation rate is desired to makes it effective.
Due to the oxidative damage and lacking of protective histones, the mitochondrial genome has a very high mutation rate, 10- to 17-fold higher than that observed in nuclear DNA.
After all, viruses -- including Ebola -- tend to have very high mutation rates.
We found that while increases in mutation rates easily overcame any presumed benefits of purging, very high mutation rates yielded an unexpected increase in fitness.
The virus very high mutation rate is capable of eluding the effects of competitive inhibition based drugs in a very short time [6].
