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Additionally, synergy may allow two drugs, both less than 50% efficacious, to be combined to achieve a very high efficacy [ 31].
Most of them exhibited low micromolar range of potency and very high efficacy.
We can eradicate malaria, but we need investment: From a biomedical research perspective, it will be most important to find a malaria vaccine candidate that shows very high efficacy against malaria infection.
A single treatment with toltrazuril resulted in a significant reduction of oocyst excretion over the study period compared to the control, with very high efficacy values during the first 2 3 weeks after treatment, irrespective of the treatment protocol and the management system applied.
The most relevant therapy characteristics represented by mean assessments of more than 90 points were: – Self-application of the drug is possible, – Drug has very high efficacy, – Long term (hidden) side effects are unlikely.
In the direct measurement the most relevant therapy characteristics were "Self-application of the drug (at home or on-the-go) possible", "Drug has very high efficacy (reduction of viral load)" and "Long term (hidden) side-effects (e.g. organ damage) is unlikely".
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The very high contraceptive efficacy of implants comes from consistent release of low but highly effective levels of progestin in the blood.
We show that a network- based vaccination strategy strongly depends on a very high vaccine efficacy and on a high eligibility and compliance of the people selected for vaccination.
More recently, Schlereth et al. reported about the very high antitumor efficacy of a bispecific single-chain antibody directed against Ep-CAM and CD3, which enables the efficient redirection and activation of tumor-resident T-cells [ 42].
Requests for information or registrations for sessions, albeit technically behavioural measures, were not accepted, as such behaviours are predicted by very different determinants from target behaviours (e.g., whereas self-efficacy for requesting information about quitting smoking can be assumed to be very high, self-efficacy for actually quitting is likely lower).
Effect of different delivery modalities: The addition of boosters to the EPI for all transmission settings has minimal effect on the effectiveness of BSV, though we observe small gains by adding boosters to the EPI at very high vaccine efficacies, or short half-lives.
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