Clues to a lipid connection were provided by the very earliest studies in which UPR components were first identified.
Even the very earliest studies of "Asian rickets" illustrated the protective impact, particularly for this population (generally impoverished and poorly housed in crowded inner-city areas), of the availability of fortified welfare foods.
Exposure pathway studies revealed that children were most commonly exposed to deteriorated lead-based paint and the contaminated settled house dust and soil it generated (Bornschein et al. 1987; Charney 1983; Lanphear and Roghmann 1997; Lanphear et al. 1998), although the very earliest studies had also suggested the importance of contaminated dust and soil from paint (Gibson 1904).
In December, a very early study of a drug by a Dutch company, Prosensa, showed promising results.
Conversely, a very early study by Shyu & Lin explored a possible effect of ASA on painful tooth stimulation in conscious monkeys, finding a significantly elevated pain threshold after ASA administration into the anterior hypothalamic area but not after injection of ASA into the periaqueductual grey matter or dorsal raphe region [14].
The letter "O" stood for "outside California" in a very early study focused on the Los Angeles region that was conducted by the U.S. Centers for Disease Control and Prevention.
A very early study by Piperno and colleagues [ 13] was performed with the prototype to the TransScan TS2000.
Interestingly, this finding echoes, or rather amplifies, findings from a very early study of high-rise living in Glasgow in the 1960s (Jephcott and Robinson, 1971, p. 55).
A very early study had already postulated an empirical distinctiveness of professional and non-professional help due to an inadequate performance of item 7 of the MHLC-A in their clinical sample [ 81].
This has been shown in a very early study conducted by Pallas et al. (1996) [ 20], where PAL-suppressed tobacco leaves did not result in the induction of downstream PR proteins in systemic leaves which therefore impaired an active defence response against TMV.
