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Applied Biosystems software packages including 4000 Series Explorer (v3.6 RC1) with Oracle Database Schema Version (v3.19.0) and Data Version (3.80.0) were used to acquire both MS and MS/MS data.

The component was configured to use MetaMap with UMLS2013AB as the knowledge source and USAbase as the data version and strict data model.

Images were extracted with Agilent Feature Extraction version 9.5.3.1 and data analyzed with Rosetta Resolver version 7.2 gene expression analysis system (Rosetta Biosoftware, Cambridge, MA).

The SNP information was collected using Data Collection Software version 3.0, and data were analyzed by the GeneMapper Software version 4.0.

Data was computerized using EpiData version 3.1 and data analysis was performed using Stata version 11.

Different bases transfers were made through STAT-TRANSFER version 9 and data were analysed using the STATA® version 13.0 software.

Images were analyzed using Agilent Feature Extraction (version 8.5) and data were analyzed using Agilent CGH Analytics (version 3.4.27).

The hybridized slides were scanned using Agilent DNA Microarray Scanner (Software Version 6.1) and data points were extracted using Agilent Feature Extraction software (Version 8.1).

Data were entered using Microsoft Excel 2002 (version 10) and data analysis was performed using SPSS Statistics 15.0.

version 12.0, and data were expressed as the mean ± the standard error.

All analyses were performed using SPSS, version 14, and data are presented as mean ± SE.