We substantiated the versatility of this RNAi delivery system by demonstrating its effective delivery of both siRNA and miRNA into three different human cancer cell lines (144B, DU145, and HCT116) and into HCT116 tumor-bearing mice by intravenous injection.
Likewise, the modular versatility of this drug delivery platform has been proven by linking drug-encapsulated Ls with an epidermal growth factor receptor (EGFR)/HER1 targeting/internalizing antibody and demonstrating the significantly improved efficacy and specificity of anti-EGFR ILs against EGFR overexpressing human breast cancer xenografts.
The scientists caution that the findings are a long way from human application, but say that the simplicity and versatility of the drug-delivery system make it an ideal candidate for translation into clinical use.
In particular, cell membrane-camouflaged nanoparticles are a new class of biomimetic nanoparticles that combine the unique functionalities of cellular membranes and engineering versatility of synthetic nanomaterials for effective delivery of therapeutic agents.
The versatility of nanoparticles also allows target delivery of genetic molecules into the cells.
This very unusual, serendipitously discovered mechanism further extends the versatility of targeted nanocarriers for intracellular delivery.
However, there has to date been no reported study on the interaction of this polycationic toxin with DNA and further information is required on the mechanism of transfection and the versatility of macromolecule (DNA or siRNA) delivery.
Because of the versatility of an nanodiamond-based drug delivery platform, future application of nanodiamonds could expand its conjugations and functional modifications including the addition of other ABC transporter effluxed drugs as well as active targeting components such as antibodies or peptides against tumor cell surface proteins for targeted drug release.
On the other hand, the main characteristics of LED use are price and versatility in light delivery on difficult anatomic area [ 21].
Different from other complicated designs of CR-ASD formulations such as an osmotic pump system, PHEMA provides versatility of designing either IR or CR delivery systems for amorphous pharmaceuticals using the same hydrogel matrix.
These observations demonstrate the versatility of mT3 E. coli as a protein delivery system and suggest that it could be used for multiple therapeutic applications.
