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Thus, a small group of proteins, believed to be present only in halobacteria and having a limited number of functions (proton and chloride pumps and phototactic/photophobic receptors), grew into a confounding variety of species with versatile sequences, ecology, taxonomy, and functions.
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Here, we have developed a microarray data analysis approach based on the similar concept as the simple, yet highly powerful and versatile sequence alignment comparisons (e.g. BLAST) for matching an unknown test DNA sequence against a comprehensive reference database of previously sequenced samples.
An extension of the original model, termed the relaxed existence model, allows a more versatile operating sequence to be used since a superstructure of all possible operations may be specified.
By means of a functional auxiliary probe pair and a versatile initiator sequence, a linear DNA concatemer structure can be formed via spontaneous and continuous polymerization of DNA oligomers in the presence of target sequence.
Finally, for the construction of a realistic read data set, MetaSim includes a versatile read sequencing simulator.
We introduce the online server for PRALINE (http://ibium.cs.vu.nl/programs/pralinewww/), an iterative versatile progressive multiple sequence alignment (MSA) tool.
In addition to using keyword queries or sequence tags (such as molecular mass or isoelectric point of a protein) the database provides a versatile way to identify sequences from the biological knowledge viewpoint.
For example, the LacI-family TF CytR in E. coli exhibits a more versatile binding of operator sequences than LacI (i.e. has a higher motif degeneracy).
Additional differences can be noted when considering tag-based platforms against array hybridization methods: While an array hybridization technique is highly versatile in identifying homologous sequences of microorganisms, current microarray design limits identification to a finite number of candidate microbes.
EST sequencing is a versatile approach for rapidly gathering protein coding sequences.
Overall, we conclude that array-based sequence capture followed by NGS offers a versatile tool for successfully selecting sequences of interest from a total human genome.
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