The genetically tractable rodent malaria parasite, P. berghei, allows both in vitro and in vivo experimental access to its complete life cycle, providing a powerful platform upon which a versatile protein regulation tool can be imposed.
Moreover, the observation of two apicomplexan subtrees (supplementary fig. S3 b, Supplementary Material online) reflects an early gene duplication that is suggestive of a complex metabolism or of a more versatile gene regulation in this alveolate lineage.
The resulting nanosized SCL assemblies exhibit versatile structural regulations in a fully reversible manner in response to changes in pH and temperature.
Thus, it is speculated that this novel characteristic trait may be well encrypted within its conserved regions which is part and parcel of its versatile function and regulation as a histone deacetylase.
Consequently, these channels exhibit one of the most versatile patterns of regulation known for any class of ion channel (Honore, 2007; Cohen et al, 2009; Mathie et al, 2010).
CTCF has a versatile role in genome regulation including transcriptional regulation, e.g., c-Myc[ 2, 3], X chromosome inactivation [ 4], allele-specific silencing at imprinted loci such as Igf2/ H19[ 5- 8], and regulation of expression of lineage-specific gene clusters such as the β-globin locus [ 9] and the MHC class II locus [ 10].
These were suggested to underlie the extremely versatile and complex transcriptional regulation of Mediator.
In addition, miRNAs have also been reported to induce upregulation of translation of target mRNAs [ 21– 23], making these molecules highly versatile components of gene regulation and function.
AMPK has versatile functions in the regulation of cellular energy metabolism, some of which overlap with and enhance the effects of insulin, such as the augmentation of glucose uptake in peripheral tissues [ 94].
In recent years, the versatile nanotechnology employed in TME regulation has made great progress.
