The azide has proven to be the most versatile bioorthogonal functional group for metabolic labeling of glycans, because it is small, abiotic, and stable in cellular systems.
Over the past several decades, enantiocontrolled allylic substitution has emerged as a fundamental process in organic synthesis, allowing efficient formation of C C, C N, and C O bonds with concomitant production of a versatile alkene functional group.
In this study, a potent TLR7 agonist was conjugated to phospholipids, poly ethylene glycol) (PEG), or phospholipid-PEG via a versatile benzoic acid functional group.
Basic hydrolysis of the 9-benzylnitrile of compound 1 (8) provided a versatile benzoic acid functional group (5) in 85% yield and allowed for the assembly of conjugates 6, 8, and 9 (Scheme 1).
Herein we have advanced a facile and versatile strategy to uniformly incorporate targeted functional groups into defect porous organic frameworks (dPOFs) by one-pot copolymerization of low-connected functional and primitive multi-connected building blocks.
These functional groups usually lead to the versatile role of l-cysteine during the synthetic process, such as sulfur sources, polydentate ligands, self-assembly reagent, or even shape-controlling agent [25 32].
Production of a large variety of chemically active functional groups makes it fast, effective and versatile technique for surface activation.
To create this technology, we developed a new class of DNA-based aptamers enabled by a versatile chemistry technology that endows nucleotides with protein-like functional groups.
However, this approach is far from being versatile since it relies on the availability of compatible functional groups on both PEG and the host surface as well as on their respective surface densities.
