Though application of the surrogate endpoints identified in this study may be suitable for these traditional chemotherapeutic agents, surrogate endpoints should be directly verified in trials evaluating targeted or immunological therapies, which have totally different pharmacodynamic profiles.
CS-linked trial-over-trial depression of simple-spike firing was demonstrated before (Medina and Lisberger, 2008), and we have verified here that trial-over-trial depression results partly from single-trial plasticity.
The F.D.A. oversees drug safety, but, according to a 2007 H.H.S. report, it conducts "more inspections that verify clinical trial data than inspections that focus on human-subject protections".
This evidence from phase II trials is being verified in phase III trials, including a trial outlined in Table 4, which should provide more level 2 evidence of the effectiveness of aliskiren as monotherapy on blood pressure reduction in patients with mild-to-moderate hypertension.
Its anti-tumor activity in lung cancer has not been included in on-going trials but could be verified in subsequent trials, subjecting to more in-depth studies and structural optimization.
Through the various model tests, it can be stated that even such a very exceptional dimensioned single screw monohull is able to maintain sufficient maneuverability by careful design and integration of the hull form and rudder, which is verified at sea trial.
In our study we tested chronic lithium dosing in an effectively powered, sibling matched, gender balanced, transgene copy number verified, investigator blinded trial using the high-copy SOD1G93A mouse.
The potential of this strategy was verified by a trial study.
70 Another trial verified an improvement in pulse-wave velocity after treatment with L-thyroxine.
The rotational speed was verified during each trial with the aid of a laser revolution counter (PCE-DT62, PCE Group GmbH, Arnsberg, Germany).
