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Many of these transcription regulators have been experimentally verified to regulate the secondary cell-wall synthesis or the biomass formation [ 25, 31- 33], such as members of the MYB, NAC and WRKY families.
Both genes were verified to regulate biofilm formation through gene knockout experiments.
Moreover, a network connecting Runx2, SATB2, and the miR-23a 27a 24-2 miR-23a 27a 24-2fied to regulate the osteoblast differentiation program.
Moreover, the E3 ubiquitin ligases Smad ubiquitin regulatory factor 1 (Smurf1) and C terminus of Hsc70-interacting protein (CHIP) were verified to regulate negatively osteoblast differentiation by promoting Runx2 ubiquitin-dependent proteosomal degradation.
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Until now, miR-126, the only microRNA has been verified to directly regulate the PLK2 gene [ 34].
In 2010, the phytohormone brassinosteroid was verified to control male fertility by regulating the expression of key genes involved in Arabidopsis anther and pollen development, such as SPL/ NZZ, EMS1/ EXS, DYT1, TDF1, AtMYB103, AMS, MS1, and MS2[ 4].
IAA18/ 28 was verified to cross graft unions and move into root tips to regulate root architecture [ 12].
The overall mechanism of color change was verified to be corresponding to the different redox states of PANI regulated by Cu species during the photochromic process.
Specially, a new method to verify the plant capability to regulate voltage at POI is proposed and used.
REDfly collected experimentally verified CRMs in the literature that were unambiguously demonstrated to regulate target gene expression through reporter gene assays.
A computational pipeline was developed to verify the hypotheses that human TPGs may generate esiRNAs to regulate protein-coding genes.
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