Exact(10)
Based on experimentally verified target genes, Target-align and psRNATarget were developed for plant miRNA target detection [ 14, 15].
According to TarBase [ 35] and miRTarBase [ 36], hsa-miR-148a has one and seven experimentally verified target messenger RNAs, respectively.
Diagnostic features were then extracted from experimentally verified target sequences to aid the prediction of AR-type FIH substrates and give an estimate of their overall abundance.
A bioinformatic approach was used to identify experimentally verified target mRNAs of the validated miRNAs in our series, miR-107 and miR-99a-3p.
Validated targets module of miRWalk was also used to investigate hosts experimentally verified target genes of differentially expressing miRNAs in the study (http://www.umm.uni-heidelberg.de/apps/zmf/mirwalk/) [ 64].
The verified target genes v-erb-b 2 and 3 avian erythroblastic leukemia viral oncogene homolog (ERBB2/3), also named human epidermal growth factor receptor (Her) 2 and 3 [ 40] are heavily upregulated in many invasive mammary carcinomas [ 41].
Similar(50)
Only a few experimentally verified target-ligand interactions were ranked outside of top 20.
In relation to existing computational methods, ExprTarget shows a greater predictive power to discriminate the experimentally verified targets based on ROC curve analysis.
Experimentally verified targets are underlined, n.a.: no category assignment.
Numerous sRNAs have already been identified, but the number of experimentally verified targets is considerably lower.
Next, pathway analysis was performed using experimentally verified targets of miRNAs from each platform.
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