The verification of this step follows the same pattern as in the verification of Step 4 in the proof of Theorem 3.1.
No one had challenged P5 nuclear disarmament announcements, but focusing on verification of P5 steps could cast doubt on those achievements and raise questions about aspects of the dismantling such as the retention of the plutonium pits at the center of the warhead (which actually renders it less susceptible to therft or diversion than would grinding down the material).
Process technology comprises the application of fundamentals to processes, as for example phase equilibria and reaction kinetics, the verification of process steps, as for example in specific reactors, and the design of process sequences to produce a product (energy) from raw materials.
The verifications of particular steps of the proposed algorithm are illustrated using real road-traffic images, while the overall algorithm is tested using both synthesized sequences of images and the ones acquired in real driving.
The verification of the three-step model with the MSH2 variations demonstrates that STEP2 is sufficient to assess the pathogenicity of 22/26 MSH2 VUS.
Here, the STEP3 assays differ slightly between the three genes but have been included for all variations for the verification of the three-step model.
The 74 MMR VUS included in this study are found in families suspected to have LS, and hence compose an appropriate and realistic panel of variations for the verification of the three-step assessment model.
The verification of the three-step model with the MLH1 variations demonstrates that STEP3 often supports the deductions, which, however, can be made from STEP2 analyses in the case of 27/37 variations.
The applicability of the model is further challenged by the lack of reliable in silico predictions for MSH6 alterations and only if MSH6 deficiency is indicated by STEP1, or by the exclusion of other causative mutations, the verification of the three-step model is feasible.
Even though the 11 MSH6 variations do not compose an ideal data set for the verification of the three-step model in assessing VUS pathogenicity, the importance of the interpretation of tumor IHC data prior to the identification of the VUS taken for further assessment is highlighted.
