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Interestingly, the verification data on the SZ twins highlighted an even larger difference (average 15% hypomethylation) in DNA methylation between the affected and unaffected twins than that was detected on the array at this site.
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ICA was also performed on the verification data using the same parameter setting as on the saliva data.
Only the best networks, characterized by the highest R value (see Eq. (8)) on verification data, are kept.
The resulting identified model shows a standard deviation of 0.2 0.3 °C on the verification data.
Whilst its confusion matrix on the verification data is in the middle of Table 2 (The corresponding matrices for GGGG are given in at the bottom of Table 2).
Although valuable as a source of data on intent to emigrate, the difficulties with verification data are multiple: health professionals may emigrate without applying for verification, they may apply for verification retrospectively (after emigration has already occurred), they may apply for verification on several occasions, or they may apply and not follow through with emigration [ 17].
Verification data may be subject to manipulation as health professionals can use verification requests to pressurise employers and/or governments to initiate debate on health professional emigration or working conditions [ 17].
Overall, comparable effort has been expended on gathering and verification of data on BRCA1 and BRCA2 mutation families.
The previously reported Affymetrix SNParray data [ 15] was used for verification of our BACarray results on tumors common to both studies (n=15) and for verification of our data on presently unique tumors (n=19) new original SNParray data was produced.
As a further means of verification, published biochemical data on translation factor activities can be used to validate protein synthesis rates predicted from the genome wide datasets.
The medical records and other documents will be reviewed for verification of agreement with data on the CRF.
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