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Over 3 years, rates of whole brain atrophy (p < 0.001), left and right hippocampal atrophy (p = 0.001, p = 0.023), and ventricular expansion (p < 0.001) were associated with baseline β-amyloid load.
The results of echocardiography, magnetic resonance imaging, and histological analyses suggest that the transplantation of hAFSC beads into an infarcted heart could effectively maintain its gross morphology, prevent successive ventricular expansion, and thereby improve the post-infarcted cardiac function.
right ventricular expansion index.
Figure 7 Identified right ventricular expansion index (RVEI, defined as RVEDV/LVEDV) during the porcine trials (top) and comparison of the modeled to measured mean RVEI (bottom).
Furthermore, the modeled right ventricular expansion index (the ratio of right to left ventricular end diastolic volumes) closely followed the trends seen in the measured data (R2 = 0.92) used for validation, with sharp increases seen in the metric for the two pigs in a near-death state.
Increased ventricular expansion was seen in the AN-1792 study with some suggestion of greater ventricular expansion relative to global brain loss.
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Alternatively, these differences may arise due to ventricular expansions in sSCA disorders, which would likely alter the lower boundary of the CC most readily due to its immediate adjacency to the ventricles.
Similarly, Carlson and colleagues showed that rates of ventricular volume expansion are greater in subjects who go on to develop MCI, and that the rate of expansion increases in the 2 to 3 years prior to clinical MCI diagnosis [ 86].
Overexpression of miRNA-1 in the mouse developing heart has a negative effect on muscle proliferation as it targets the transcription factor that promotes ventricular cardiomyocyte expansion, Hand2 [4].
It is increased in response to ventricular volume expansion and pressure overload[ 5, 6].
BNP and its amino-terminal fragment, NT-proBNP, are mainly produced by myocytes in response to a ventricular volume expansion or pressure overload.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com