Sentence examples for ventricular action potential duration from inspiring English sources

Using high-resolution video microscopy and optical voltage mapping we have demonstrated depression of cardiac contractility indices and a significant increase in ventricular action potential duration at 48 hpf following loss of hadp1.

Perhaps surprisingly to some clinicians, the authors found an increased action potential duration in the atria of this heart failure model, although increased ventricular action potential duration in failing hearts is a well accepted hallmark.

These observations suggest that β-adrenoceptor-blockers may not only blunt the beneficial effects of catecholamines on ventricular action potential duration and QT interval in vivo, but inhibit beneficial effects of 'endogenous' catecholamines in the heart, e.g. stemming from spontaneous release and incomplete re-uptake of sympathetic granules from sympathetic nerve endings.

Although we understand how hERG channel inhibition can prolong ventricular action potential duration and the QT interval in vivo, most of this knowledge has been derived from retrospective studies of human torsadogenic drugs in animal models (Omata et al., 2005; Hanson et al., 2006).

The QT interval, from the onset of the QRS complex to the end of the T wave, is a reflection of the summed ventricular action potential durations in the heart [ 23].

As with the human disease, the zebrafish KCNH2 mutant breakdance exhibits prolonged ventricular action-potential duration, spontaneous early afterdepolarizations and 2 1 AV block (two atrial contractions for each ventricular contraction), which is easily observed at the embryonic stage (Langheinrich et al., 2003).

Dissimilar lengthening of left ventricular and right ventricular monophasic action potential duration increased the interventricular dispersion significantly from 55 to 110 ms for both drugs.

Initially, beat-to-beat variability of repolarization was assessed from beat-to-beat STV derived from left ventricular monophasic action potential duration, that is STVLVMAPD, in anaesthetized chronic atrio-ventricular block dogs (Thomsen et al., 2004).

Hypokalemia-induced arrhythmogenicity is due to slowed conduction, prolonged ventricular repolarization, and action potential duration associated with shortening of the effective refractory period enabling reentry, abnormal pacemaker activity, and early and delayed afterdepolarizations [ 87].

At each ventricular node, the the action potential duration at 90% (APD90) is computed as the time interval between the depolarization time and the time at which the transmembrane potential is 90% repolarized.

Another important concept in the generation of ventricular arrhythmias is that of action potential duration dispersion.