Exact(1)
Injurious ventilation consisted of zero PEEP (0 cmH2O) and titrated VT, such that Pplat was 30 cmH2O.
Similar(59)
BALF cells from control, non-ventilated mice and from mice subjected to 60 min of mechanical ventilation consists of >85% alveolar macrophages (data not shown).
We have shown that protective ventilation, consisting of medium low VT of 6 ml x kg−1 and medium high PEEP of 10 cm H2O, affects the bacterial burden in the lungs during experimental pneumonia.
Partial liquid ventilation consists of filling the residual functional capacity with perfluorocarbon (PFC), while providing tidal volume by conventional ventilation.
Single lung ventilation consists of using a dual-lumen intubation tube allowing single ventilation of the lung on the opposite side to the treated organ, thus minimising motion of the contralateral abdominal organ.
Reis et al. investigated the effect of open lung ventilation, consisting of low VT (4-6 ml/kg) with moderate-high PEEP levels (10 cmH2O) and recruitment maneuvers, on inflammatory mediators.
In contrast to the previous studies, Severgnini et al., comparing a lung protective mechanical ventilation consisting of a VT of 7 ml/kg ideal body weight with PEEP levels of 10 cmH2O and recruitment maneuvers versus a VT of 9 ml/kg without PEEP, showed beneficial effects of the lung-protective strategy during general anesthesia lasting more than 2 hours [ 26].
A strategy of protective ventilation, consisting of low tidal volumes and plateau pressures and application of positive end expiratory pressure (PEEP) has gained widespread acceptance in intensive care units after large studies showed an associated reduction in morbidity and mortality in patients with acute lung injury.
The injurious ventilation, consisting of high tidal volumes and low PEEP, led to more apoptotic cells in the kidney and small intestine and less apoptotic cells in the lung; no increased apoptosis of liver cells in either group was detected [ 3].
This approach also requires highly efficient and energy saving methods for modern building ventilations consisting of a set of parameters of the complex indoor system.
Conventional mechanical ventilation (CMV) consisted of volume-controlled ventilation with 5 cmH2O positive end-expiratory pressure and a tidal volume of 8 10 ml/kg.
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