After 210 min of high VT ventilation, lung compliance decreased in WT mice to 60% of control, but not in Tpl2-/-mice (93% of control; Figure 2).
Soon after, minute ventilation, dynamic compliance, airway resistance and respiratory frequency were registered by MV.
Lung function was assessed by hypoxia score (HS = PaO2/FiO2), PEEP level, dead space ventilation, lung compliance, and venous admixture.
During high-stress ventilation, lung compliance was significantly reduced by the presence of TPO in the perfusate.
Tidal volume, minute ventilation, respiratory compliance, and FRC determined by SF6 multiple breath washout (representing the lung volume in actual communication with the airways) were significantly lower in former BPD infants compared to controls.
At each PEEP step, EIT measurements were performed and from this data the following were calculated: tidal impedance variation (TIV), regional compliance, ventilation surface area (VSA), center of ventilation (COV), regional ventilation delay (RVD index), global inhomogeneity (GI index), and intratidal gas distribution.
To test the hypothesis that an educational intervention would improve the resuscitator's ability to provide on-target volume ventilation during pulmonary compliance changes.
Male Sprague Dawley rats were anesthetized, oro-tracheally intubated, and subjected to high stretch mechanical ventilation until lung compliance had declined by 50%% of baseline.
During two-lung ventilation, the dynamic compliance (Cdyn) and the arterial oxygen tension to FIO2 ratio (P/F) of her lungs were approximately 30 mL/cmH2O and more than 500, respectively, and the CVP was 4 8 mmHg.
