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Subjects: Forty-five preterm infants of <37 weeks gestation, being mechanically ventilated within 24 h after birth.
In contrast, we found a significant relationship between lung weight increase and dynamic strain applied in the 38 pigs ventilated within the limits of inspiratory capacity ("Within" group).
Similarly, the 20 pigs ventilated within the limits of inspiratory capacity which finally died had significantly higher dynamic and global energy loads (2.02 ± 1.00 and 2.28 ± 0.86 J) than the 18 pigs that survived (1.20 ± 0.54 J ( P = 0.004) and 1.47 ± 0.45 J ( P < 0.001) (Fig. 5).
All infants with RDS who were supported with ENCPAP but failed and were intubated and ventilated within 72 hours after birth (ENCPAP failure = ECF group) were selected for the study group.
All patients were mechanically ventilated within the first 24 hours after ICU admission.
Animals were anesthetized with ketamine-xylazine, tracheostomized and mechanically ventilated within a plethysmograph chamber.
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In the Within group ventilated with a high dynamic strain, there was an increase in edema, associated with a sharp deterioration of gas exchange and impaired lung mechanics, and 54 % of the animals died.
In contrast, in the group ventilated with end-inspiratory volumes within inspiratory capacity ("Within" group) at the end of the experiments, pulmonary artery pressure and heart rate were both significantly increased, with significant drops in mean arterial pressure and central venous oxygen saturation.
For instance, rats ventilated with a tidal volume within the physiologic range developed pulmonary edema when a 15 cm H2O but not a 10 cm H2O PEEP was applied [33].
For instance, rats ventilated with a tidal volume within the physiologic range developed pulmonary edema when a 15 cm H2O but not a 10 cm H2O PEEP was applied [ 33].
With the advent of hyperpolarized helium-3 magnetic resonance imaging (HP 3He MRI), there is now a noninvasive method to directly visualize areas of ventilated airspaces within the lung [27 36].
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