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The method provides direct visualization of the ventilated regions within the lung.
Inhaled NO is a selective pulmonary vasodilator that acts preferentially on ventilated regions.
Hypoxic pulmonary vasoconstriction (HPV) optimizes pulmonary ventilation perfusion matching in response to alveolar hypoxia, thereby diverting blood away from poorly ventilated regions of the lung.
First, the WI-WO technique measures volume of lung regions that may be reached by nitrogen (and hence are ventilated), while CT measures aeration of both ventilated and non-ventilated regions.
This additionally supports the hypothesis that INO acts by two distinct mechanisms; one is vasodilation in ventilated lung regions, and the other is vasoconstriction in poorly ventilated or nonventilated lung regions.
Further support is added to the hypothesis that inhaled nitric oxide acts by two distinct mechanisms; one is vasodilation in ventilated lung regions, and the other is vasoconstriction in poorly ventilated or nonventilated lung regions.
PEEP may increase the end-expiratory lung volume either by increasing the proportion of aerated alveoli at end-expiration or by further inflating already ventilated lung regions.
Since EELV and ELV are assessed by analyzing the dynamics of the expired gas, these measures provide information only about the size of the ventilated lung regions.
The shape of the P V curve from EIT data, in particular the increasing slope (lower level > upper level), reflected the recruitment of poorly ventilated lung regions.
In the present study we used a decremental PEEP trial and, as long as the PEEP level is adequate to keep the dependent lung region open, the used pressure amplitude of around 10 cm H2O was sufficient to ventilate this region; however, after collapse the inspiratory pressures are too low to open up this dependent region.
Calculate the fraction of emitted NO x that is oxidized within the region (vs. ventilated out of the region).
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CEO of Professional Science Editing for Scientists @ prosciediting.com