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Next, 7-day old rat pups were ventilated for all subsequent experiments.
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We included 58 adult ICU patients, all mechanically ventilated for a minimum of 48 hours, of whom 93%% were surgical patients.
All neonates were ventilated for an average of 137.5 min (range 90-180 min) prior to NO therapy.
Patients were ventilated for a variety of reasons.
Twenty (100 %) were mechanically ventilated, for a median of 17.5 days (9.5-32 9.5-32
Patients in group II were ventilated for a minimum of 3 hours after surgery.
These patients were ventilated for a median of 11 days.
Second, the test was discontinued immediately at the first sign of respiratory insufficiency and these patients were then mechanically ventilated for six hours; all of these patients went on to tolerate a new 120-minute weaning trial; thus, it is unlikely that they would have developed muscle fatigue.
These criteria excluded all patients ventilated for CAP or for abdominal sepsis and all immunocompromised patients receiving antibiotics, among others.
While ventilator-associated pneumonia (VAP) can affect all patients ventilated for >2 days in an ICU, an issue during the last two decades has been identification of a universally accepted definition.
We performed a prospective observational study in all patients ventilated for greater than 48 hours.
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