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Three operation parameters (vent time, vent flow and vent pressure) were optimised by applying a D-optimal experimental design.
The methods, however, were robust with respect to small changes in split vent time, GC column flow and FID temperature.
Among these variables, vent time showed the highest effect on the analytical response (signal intensity) of the target PAHs.
Among the variables studied for in-port derivatization, vent time, cryo-focusing temperature and the ratio solvent volume/N,O-bis trimethylsilyl trifluoroacetamide (BSTFA) volume were optimized using an experimental design approach.
Experimental designs such as Plackett Burman (PBD) and central composite designs (CCDs) were used to optimize the LVI-PTV variables (cryo-focusing temperature, vent time, vent flow, vent pressure, injection volume, purge flow to split vent, splitless time and injection speed).
Reoperation significantly increases morbidity (low cardiac output, acute renal failure, sepsis), vent time, ICU stay and mortality [ 8]; also cost [ 1].
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Since temperature inside the reactor is not high, the venting time can be shorted to 15 min.
For PAHs, the recommended optimized settings of the specially-designed pcGC cooled injection system (CIS) and preparative fraction collector (PFC) are: 5 s CIS solvent venting time, deactivation of CIS "stop flow" injection mode, autoinjector "fast injection" mode, 60 s CIS splitless time, 340 °C PFC switch temperature, and 30 °C (ambient) trapping temperature.
The DTVS model is established in the GOTHIC model based on the venting size, venting piping loss, venting initiation time, and venting source.
Comparison of the results of the proposed model to experimental data shows that the model predicted top vent clearance time, the pool swell height, and the bubble breakthrough elevation are within 10% of the data.
b Flow thickness (mm) 24.5 cm downslope of the vent with time since the flow front reached that distance.
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