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In the same vein, model averaging is used to compute posterior predictive distributions (see Supplementary Material).
In accordance with these in vitro data, ΔNp63 or miR-205 significantly inhibited the incidence of lung metastasis in vivo in a mouse tail vein model.
We also find that neointimal development was completely inhibited by CCR5 antagonists in a human saphenous vein model of accelerated intimal hyperplasia.
Volume flow rates of 1.45 l/minute and 200 ml/minute were achieved in the central vein model and the HDF circuit model, respectively, with laminar flow in the central vein confirmed by Duplex imaging and ink flow analysis.
Previously, we found that α2AP(13-42 -HSA was no more likely to be present in vivo in the rabbit jugular vein model of thrombosis than recombinant HSA [ 19].
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For this technique, femoral artery-vein and saphenous artery-vein models were the most widely used to construct the AV-loop.
CAPNb2 markedly restrained the occurrence of lung metastases in both the orthotopic and tail-vein models (>90% reduction in photon flux).
Notably, the nanobody prevented formation of lung metastatic lesions in orthotopic xenograft and tail-vein models of metastasis in immunodeficient mice.
However, the findings reported here suggest that this may not necessarily hold true at the protein level or under pathologic conditions, because CAPNb2 reduced metastatic spread by >95% in orthotopic and tail-vein models of metastasis by preventing CapG from binding to actin filaments and regulating their polymerization status.
To confirm the neutralizing effect of MT95-4 APN/CD13APN/CD13 in vivo, we established a tail vein metastasis model and a subcutaneous xenograft model using APN-B16 cells and administered MT95-4 (1 mg/kg) i.p. twice per week in tumor-bearing mice.
The tail vein metastasis model is inherently an acute model as mice develop a heavy metastatic load in the lungs at two weeks and need to be euthanized for humane reasons.
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