Sentence examples for vector with enhanced from inspiring English sources

Todo, T., Martuza, R. L., Rabkin, S. D. & Johnson, P. A. Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing.

Therefore, using several diverse AAV capsid libraries including randomly mutagenized, DNA shuffled, and random peptide insertion variants we applied directed evolution to create a "designer" AAV vector with enhanced delivery efficiency for neural stem cells (NSCs).

Our findings suggest that this modified rNDV can be used safely as a vaccine vector with enhanced replication, expression, and protective efficacy in avian species, and potentially in humans.

In an attempt to design more sophisticated vectors with enhanced transfection efficiency and targeting ability, the cell-binding ligand transferrin has been incorporated into polyethylenimine formulations.

These efforts resulted in next generation vectors with enhanced capabilities, that is increased efficiency of cell transduction, targeted transduction of previously non-permissive cell types, escape from antibody neutralization and off-target free in vivo delivery of vector genomes.

This structure of AAVrh.8 thus identified capsid surface differences which can serve as template regions for rational design of vectors with enhanced transduction for specific tissues and escape pre-existing antibody recognition.

Recent developments in understanding the molecular mechanisms of myocardial disease have led to the identification of new therapeutic targets, and the availability of vectors with enhanced myocardial tropism offers the opportunity for the design of gene therapies for both protection and rescue of the myocardium.

Investigation of the host-cell determinants of permissiveness to VSV infection has become particularly essential for the optimization of viral vectors with enhanced oncolytic properties in HCC, while simultaneously maintaining attenuation in the normal surrounding liver tissue, resulting in a wider therapeutic index.

(5, 7, 24, 25) While recent improvements in developing new generations of oncolytic Ad vectors with enhanced efficacy and specificity are remarkable, 26 noninvasive monitoring of CRAd replication remains a challenge.

A novel mutation in the FIX gene was discovered to enhance its catalytic activity, 57 and this so-called "Padua" mutation has been shown to provide AAV vectors with enhanced potency.

A new generation of Salmonella vectors with enhanced immunogenicity, defined control of attenuation, increased stability in expression and delayed in vivo synthesis of heterologous antigens has allowed improvements in protective properties of the vaccine primarily based on modified LcrV.