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Notably, infusions of MSC that had been transfected with an HGF adenovirus vector to stimulate their production of HGF have been shown to further improve survival in the setting of small for-size liver transplantation, although the relative contributions of HGF and/or MSC in this setting require further study (115, 116).
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Parvoviruses or other viruses employed as therapeutic gene vectors are used to stimulate the immune system [ 6- 8].
In this investigation, the results indicated that human normal liver cells, L-02 were transfected with HBx-expressed vectors been able to stimulate expression of AFPR priors to the expression of AFP and Src, the results implicated that AFP played important role in inducing malignant transformation of liver cells and enhancing HCC cells malignant behavior was mediated by AFPR.
We next investigated whether immunization with nonintegrative lentiviral vector particles was efficient to stimulate a specific and protective humoral immune response against West Nile Virus (WNV), a flavivirus responsible for the largest recognized epidemic of neuroinvasive human disease in North America.
Self-complementary AAV vectors (which more rapidly form double-stranded DNA than conventional single-stranded vectors) have been shown to stimulate Toll like receptor 9, which is a known pattern recognition receptor recognizing unmethylated CpG dinucleotides, and this stimulation is stronger than that which occurs with single-stranded AAV vectors.
In addition to their broad potential for therapeutic gene delivery, adeno-associated virus (AAV) vectors possess the innate ability to stimulate homologous recombination in mammalian cells at high efficiencies.
Medium derived from LNCaP-Id-1 cells had a lower ability to stimulate osteoblast mineralisation when compared with their vector control counterpart.
To stimulate the motion of discrete substructures, the concept of "admissible vectors" is introduced, where admissible vectors represent the discrete counterpart of admissible functions for distributed substructures.
Viral vectors carrying vascular endothelial growth factor (rAAV-VEGF) have been shown to stimulate mandibular growth in vivo in rats [ 95].
Oligos targeting different regions of the transduced genomes varied in their ability to stimulate intermolecular recombination, which in some cases approached the efficiency of single vector transduction.
An effective viral vector should present the expressed antigen as an immune target and should remain in the host long enough to stimulate an effective response.
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