Sentence examples for vector to induce from inspiring English sources

We infected mouse livers with sufficient PFU of this vector to induce YAP (5SA) expression in 10, 25, 60 or 80% of hepatocytes (Supplementary Fig. 7a,b).

After 24 h, cells were transfected with I-SceI expressing vector to induce DSB and the percentage of GFP-positive (GFP+) cells was measured using flow cytometry as an indicator of HR efficiency.

Here, we examine the capacity of this targeted vector to induce immune responses to the tumor antigen CEA in a stringent in vivo canine model.

To model the hippocampal neurodegeneration and memory-related behavioral impairment that occurs in FTLD and other tau and TDP-43 proteinopathy diseases, we used an adeno-associated virus serotype 9 (AAvectorctor to induce bilateral expression of either microtubule-associated protein tau or transactive response DNA binding protein 43 kDa (TDP-43) in adult rat dorsal hippocampus.

New techniques, namely the use of viral vector to induce genetic material into specific cells, might be promising for the development of new BD animal models reproducing the cyclic character of the disorder.

To examine whether PKD2 alone could trigger myogenic differentiation of C2C12 cells, we inserted wild type PKD2 into a retroviral vector to induce forced expression of PKD2 (PKD2-OE; Figure 6A).

Thus, DC-targeted protein vaccines are a potential new vaccine platform, either alone or in combination with highly attenuated viral vectors, to induce integrated immune responses against microbial or cancer antigens, with improved ease of manufacturing and clinical use.

We designed CRISPR/Cas9 lentiviral vectors to induce cleavage of the murine endogenous Eml4 and Alk loci in order to generate the Eml4-Alk gene rearrangement recurrently found in non-small-cell lung cancers (NSCLCs).

We then used OSK lentiviral vectors to induce reprogramming of cardiac cells.

To this end, the target gene hSSTr2 should be inserted into gene transfer vectors to induce transfected tumors to express SSTR2 [ 23– 25] and assure that hSSTr2 expression could occur on tumor cell membranes.

His major research contributions have resulted in the development of pioneering new approaches, for example using adenoviral vectors to induce transgene expression in primary cells that have traditionally been difficult to transfect.