When CD34+ cells were transduced with BCR/ABL RVs (plus the control Neor vector), the proportion of cells with chromosomal aberrations, specially of chromatid-type (see representative picture in Figure 8c), increased 2-fold in unexposed cells, and 3- fold in DEB-exposed cells, compared to control CD34+ cells (Figure 8a).
VC= mhpNb/-ln(p), where m = the number of mosquitoes/host, h = host feeding rate, p = the probability of daily survival, N = the mean extrinsic incubation period, and b = vector competence (proportion of exposed mosquitoes with disseminated infections).
We denote by x O [ v, m ] ∑ R q the vector of proportions of input component fluxes recovered in each output flux (for instance, the proportion of carbon from the input glucose appearing in the composition of the CO2 in blood).
Vector of proportions A is undefined.
The independent variable r for Broad-Enrich is the vector of proportions of each gene's locus that is covered by the union of all peaks (Fig. 1 visually represents these proportions).
We assume that the scalar measurement is correct and assign a weight to each vector measurement in proportion to the absolute value of dF, expressed in nT.
Our results suggest that hematopoietic cells transduced with the triple mutant are at a selective disadvantage compared to cells transduced with wild type BCR-ABL or empty vector, as their proportion was reduced after engraftment.
The proportion vector is re-normalized to sum to 1. Next, 10 samples are simulated for each condition with their OTU counts generated by the DM model with the corresponding proportion vector and the common dispersion parameter.
Consider that elements from the proportion vector of multinomial a are required the probabilities to sum to 1.
∑ is (k−1) dimensional diagonal matrix with (i,i) element being variance of i-th element (i=1,2,...,k−1) of proportion vector P1−P2.
