Sentence examples for vector modification from inspiring English sources

The major coat protein, hexon, from a chimpanzee adenovirus (AdC68) is of interest as a target for vaccine vector modification.

We have demonstrated by the use of Isothermal Titration Calorimetry (ITC) that this vector modification resulted in activity preserved for a higher period.

Each of these regions is flanked by a restriction site that allows for easy vector modification, including removal of the signal sequence without perturbation of the reading frame.

Exploiting intracellular differences between normal and cancer cells for gene delivery vector design offers a new paradigm to achieve transfection selectivity based on intracellular differences rather than conventional approaches involving vector modification using specific ligands for targeted delivery.

Since no nucleic acid production or protein expression is required during the actual vector modification, procedure times can be kept brief and modifying molecules are not limited to factors naturally produced by cells.

For instance, they've doubled the speed of simple division, and added optimizations for vector modifications.

However, limited efficacy in clinical trials using Ad-based agents has clearly exposed the need for vector modifications designed to provide target cell-specific gene delivery and expression, thereby improving efficacy and safety.

Addition of stuffer DNA and vector capsid modification are some of the other aspects that need consideration during the production of these vectors.

Delivery of the oligonucleotides, choice of vector, chemical modification to stabilize against nucleases and avoidance of side effects (e.g. stimulation of interferons) are major challenges.

In this vector, a modification on the ubiquitin (Ub) moiety makes it susceptible to cotranslational proteasomal degradation and therefore Ub-GFP is only detected in cells with compromised proteasome activity (Fortun et al., 2007).

In this report we showed that despite its popularity among scientists wishing to use an IRES-containing expression vector, this modification present in many commercial vectors actually results in a dramatic decrease in the expression of the IRES-controlled coding sequence as compared to that observed with the wild type IRES.