Sentence examples for vector integration from inspiring English sources

Insertional oncogenesis due to retroviral (RV) vector integration has caused recurrent leukemia in multiple gene therapy trials, predominantly due to vector integration effects at the LMO2 locus.

Our results highlight the risk of intragenic vector integration to initiate leukemia by inducing haploinsufficiency of a tumor suppressor gene.

In particular, BinMLV vector integration associated less with oncogene TSS compared to the MLV vectors currently used in clinical trials.

Rapid scientific and technological progress has shed much light onto this dark side of untargeted vector integration.

However, adverse events in which vector integration activates proto-oncogenes, leading to clonal expansion and leukemogenesis hamper their application.

Adverse events in otherwise successful clinical trials caused by proto-oncogene activation due to vector integration hamper their application.

In contrast to other vector systems in use for genetic engineering of CD34+ cells, rAAV-mediated gene expression does not depend on vector integration.

Our results establish a novel and simple way to engineer chromosomes in vivo and provide further insights into the mechanisms of recombinant AAV vector integration in vivo.

This is the first time that TTRAP has been shown to interact with HIV-1 IN and facilitate lentiviral vector integration.

In both cases, success has been undermined by clonal expansion of transduced cells in some patients due to insertional mutagenesis induced by random vector integration.

However, adverse events in gene therapeutic trials, caused by activation of proto-oncogenes due to murine leukemia virus (MLV -derived vector integration, haMLV -derivedpplication.