Sentence examples for vector insertion from inspiring English sources

Modlich U, Schambach A, Brugman MH, Wicke DC, Knoess S, Li Z et al. Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16.

In two different trials, vector insertion resulted in the transcriptional activation of proto-oncogenes.

In this case, the host gene encoding high-mobility group AT-hook 2 (HMGA2) produced a truncated mRNA due to vector insertion within the gene.

Vector insertion in the transgenic plants was confirmed by PCR with primers for the pMDC32 vector and OsPORA fragment (Additional file 6: Table S1).

Hence, the elucidation of vector insertion mediated oncogenesis is important to ascertain the risk of gene therapy approaches utilizing integrating vectors.

In the previous study, GT12/GT12 (a gene-trap vector insertion within intron 12 of Vrk1) tubule was stained with x-gal [17].

Varas, F. et al. Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions.

Most CBA-null vector insertions recovered from tumors were associated with known proto-oncogenes or tumor suppressors.

Genetic studies of the boys' new T-cells, which are critical components of the body's immune system, reveal that the viral vector used to deliver the gene therapy did not lead to an expansion of cells with vector insertions near known cancer-causing genes, raising cautious hopes about the vector's long-term safety.

All vector insertions were verified by DNA sequencing.

These tests indicated that few to no mutants contained incorrect/unwanted transpositions; vector insertions containing additional portions of the transposon-containing plasmid.