This review will examine the concepts and practice of prenatal vector administration.
We further demonstrate that anti-mouse F9 antibody formation in the gene-based approach can be reduced by transient immune modulation at the time of vector administration.
Following intravenous luciferase vector administration to neonatal mice, LTR1 sustained a higher level of liver transgene expression than an equivalent dose of a standard lentivirus.
A major challenge in the use of gene transfer vectors as therapeutic tools is controlling vector administration at a desired tissue site.
In skeletal muscles of the treated limb at 3-months after vector administration we report widespread vector biodistribution, and sustained high level MD expression (up to 95% of fibres).
Background & Aims: In gene-therapy protocols, imaging of gene expression is needed to evaluate the transduction efficiency of the vector, its tissue distribution, and the duration of transgene expression and to assess the feasibility of repeated vector administration.
The short-lasting cytokine production in the CNS after a single vector administration (4 weeks) is the limiting factor of this novel technology which, although promising, has to be improved.
In this article, we describe our experience with AAV viral vector delivery system, that allows us to optimize and monitor in real time viral vector administration into affected regions of the brain.
The normal retinal architecture was not disturbed by vector administration.
Anti-MPER humoral responses could be boosted after homologous Ad vector administration.
Ad5 vector administration did not alter this functional response, and instead further expanded it.
