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Both VE P and VE I condition on being infected; VE S and VE SP do not condition on infection.
Then, VE P was calculated by using the relation VE SP = 1 − (1 − VE S)(1 − VE P).
For example, when VE S = 80% and VE P = 20% (i.e., VE SP = 84%; refer to Figure 2A), we obtain a combined efficacy of 85%.
The VE P for the absolute efficacy of live vaccine was VE P = 67%, 95% CI: 24, 100, and the VE P for the absolute efficacy of the inactivated vaccine was VE P = 29%, 95% CI: −19, 76.
Live vaccine had a higher efficacy for illness given infection (VE P = 67%, 95% CI: 24, 100) than inactivated vaccine (VE P = 29%, 95% CI: −19, 76), although the difference was not statistically significant.
Note that the combined efficacy is not symmetric with respect to VE S and VE P. In fact, for high values of VE S, regardless of the value of VE P, the combined vaccine efficacy remains quite high.
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